211 次血漿ChIP-seq的cfDNA組蛋白修飾分析揭示晚期前列腺癌表型異質(zhì)性 2025-7-10
近日,美國(guó)國(guó)家癌癥研究所David Y. Takeda和加拿大哥倫比亞大學(xué)Alexander W. Wyatt、Cameron Herberts團(tuán)隊(duì)合作,利用血漿游離細(xì)胞DNA(cell–free DNA,cfDNA)的染色質(zhì)免疫沉淀測(cè)序(cfCh
265 次C/EBPβ 拮抗劑誘導(dǎo)巨噬細(xì)胞促炎極化增強(qiáng)抗腫瘤免疫 2025-7-3
The C/EBPβ antagonist peptide lucicebtide (ST101) induces macrophage polarization toward a pro-inflammatory phenotype and enhances anti-tumor immune responsesKeywords: C/EBP&b
312 次小鼠主動(dòng)脈應(yīng)力激活平滑肌細(xì)胞適應(yīng)性程序維持強(qiáng)度防動(dòng)脈瘤和夾層 2025-6-30
Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in MiceKeywords: aort
374 次成骨細(xì)胞線粒體氧化應(yīng)激或自噬減少不足以模擬衰老對(duì)骨機(jī)械反應(yīng)性損害 2025-6-24
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsivenessKeywords:
223 次苔蘚抑素-1(Bryostatin-1)通過抑制內(nèi)皮細(xì)胞自噬改善動(dòng)脈功能 2025-6-24
Bryostatin-1 improves function in arteries with suppressed endothelial cell autophagyKeywords: Aging; Bryostatin-1; Endothelial cell; Nitric oxide.內(nèi)皮功能障礙是心血管衰老的標(biāo)志,內(nèi)
268 次Piezo1 對(duì)抗與衰老相關(guān)的皮質(zhì)骨丟失 2025-6-24
Piezo1 opposes age-associated cortical bone lossKeywords: Piezo1; age-associated bone loss; endocortical bone resorption; mechanical stimulation.衰老會(huì)導(dǎo)致松質(zhì)骨和皮質(zhì)間隔的骨質(zhì)流失