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186 次壓力響應型 miRNA - 5703 的過表達抑制壓力誘導的肝癌生長和轉移 2025-7-9
Overexpression of pressure-responsive miRNA-5703 inhibits pressure-induced growth and metastasis of liver cancerKeywords: liver cancer; metastasis; miRNA-5703; portal hypertension;
141 次 ChIP-seq還是ChIP-qPCR？如何選擇？ 2025-7-8
在生命科學研究領域，探究蛋白質與DNA之間的相互作用，是理解基因表達調控機制的關鍵。染色質免疫沉淀（ChIP）技術作為研究這一相互作用的經典方法，衍生出了ChIP-seq和ChIP-qPCR兩種重要技術手
200 次成纖維細胞中張力敏感的 HOX 基因表達用于差異瘢痕形成 2025-7-8
Tension-sensitive HOX gene expression in fibroblasts for differential scar formationKeywords: Scar formation, Hypertrophic scar; Keloid; Wound healing; Tension; Tension change; Ten
174 次微量WGBS等揭示有袋類和真獸類動物胚胎中DNA甲基化動態差異 2025-7-7
近日，英國弗朗西斯·克里克研究所（FrancisCrickInstitute）James M A Turner團隊深入探討了有袋類動物（Marsupial，以負鼠Monodelphis domestica為模型）和真獸類（eutherian，即胎盤類
129 次 ChIP-seq助力揭示AcP依賴性乙酰化修飾網絡對放線菌穩態的調控機制 2025-7-7
近日，華東理工大學生物工程學院和生物反應器工程國家重點實驗室葉邦策教授和尤迪副教授為共同通訊作者、符瑜博士為第一作者在微生物學領域著名期刊《mBio》上發表題為《A network of acetyl ph
267 次 C/EBPβ 拮抗劑誘導巨噬細胞促炎極化增強抗腫瘤免疫 2025-7-3
The C/EBPβ antagonist peptide lucicebtide (ST101) induces macrophage polarization toward a pro-inflammatory phenotype and enhances anti-tumor immune responsesKeywords: C/EBP&b
314 次小鼠主動脈應力激活平滑肌細胞適應性程序維持強度防動脈瘤和夾層 2025-6-30
Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in MiceKeywords: aort
375 次成骨細胞線粒體氧化應激或自噬減少不足以模擬衰老對骨機械反應性損害 2025-6-24
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsivenessKeywords:
224 次苔蘚抑素-1（Bryostatin-1）通過抑制內皮細胞自噬改善動脈功能 2025-6-24
Bryostatin-1 improves function in arteries with suppressed endothelial cell autophagyKeywords: Aging; Bryostatin-1; Endothelial cell; Nitric oxide.內皮功能障礙是心血管衰老的標志，內
269 次 Piezo1 對抗與衰老相關的皮質骨丟失 2025-6-24
Piezo1 opposes age-associated cortical bone lossKeywords: Piezo1; age-associated bone loss; endocortical bone resorption; mechanical stimulation.衰老會導致松質骨和皮質間隔的骨質流失
258 次機械激活的間充質衍生骨細胞通過細胞外囊泡介導的機制驅動血管生成 2025-6-23
Mechanically activated mesenchymal-derived bone cells drive vessel formation via an extracellular vesicle mediated mechanismKeywords: Osteoblast; VEGF; angiogenesis; mechanobiology
190 次血管炎性疾病和內皮表型 2025-6-17
Vascular Inflammatory Diseases and Endothelial PhenotypesKeywords: EC phenotypes; endothelial cell; inflammation; vascular diseases.內皮細胞排列在管腔表面，充當分隔血液和周圍組織的
220 次蛋白與DNA互作驗證全攻略：常用方法+避坑指南 2025-6-16
在生命科學領域，蛋白質與DNA的相互作用構成了生命活動的分子基礎，精準調控著基因表達、細胞命運決定和遺傳信息傳遞等關鍵生物學過程。這種精密的分子互作機制不僅維持著生物體的正常生理功能，
154 次微管蛋白乙酰化增強機械應力下小梁網細胞的微管穩定性 2025-6-16
Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical StressKeywords: trabecular meshwork, glaucoma, tubulin acetylation, mechanical stre
337 次拉伸誘導的內皮細胞單層損傷的相關研究 2025-6-10
Stretch-induced damage in endothelial monolayersKeywords: Aging; Cell mechanics; Endothelium; Mechanobiology; Senescence; Stretch.由于血流的脈動性，包括流體剪切力、壓力和循環拉伸在
373 次視網膜神經節細胞經IL-12-SCGF-β串擾誘導干細胞衍生的神經保護作用 2025-6-9
Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalkKWS：Retinal ganglion cells；stem cell；neuroprotection；IL-12；SCGF-β；cross
438 次血管內皮-間充質串擾通過 Notch 信號驅動人成骨細胞的成骨分化 2025-6-4
Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signalingKeywords: Co-culture; Endothelial cells; Notch signaling; Osteoblast
359 次 TRPV4 抑制劑和機械負荷對減輕炎癥的協同作用 2025-6-3
Synergetic role of TRPV4 inhibitor and mechanical loading on reducing inflammationKeywords: anti-inflammatory phenotype; inhibition, mechanical loading; macrophage polarization; mi
402 次 I 類 PI3Ks 激活小梁網細胞中拉伸誘導的自噬 2025-5-27
Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cellsKeywords: Autophagy; Glaucoma; Mechanical stress; PI3K; Primary cilia; Trabecular meshwork.眼壓升高（IO
326 次內皮 IGFBP6 抑制血管炎癥和動脈粥樣硬化 2025-5-26
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosisKWS：IGFBP6；vascular inflammation；atherosclerosis動脈粥樣硬化通常發生在血流紊亂（DF）區域，例如動脈分支或彎