細胞因子索引Cytokine Index第4版免費送!先到先得!
瀏覽次數：4027 發布日期：2015-1-27
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新年新氣象， Cytokine Index(細胞因子索引)
第4版免費大派送！
厚達356頁，涵蓋370多種細胞因子，全面細致
的介紹，實為手邊必備之速查手冊！
數量有限，先到先得！ |
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書中實例：
Adiponectin
Synonyms: Acrp-30, GBP-28, APM-1, Gelatin-binding protein, AdipoQ
| Description: |
Adiponectin is an adipose-derived secreted protein containing 236 amino acid residues. It |
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is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma |
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protein.The circulating levels of adiponectin are decreased under conditions of obesity, |
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insulin resistance,and type II diabetes. Disruption of adiponectin in mice causes insulin |
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resistance and neointimal formation.Conversely, administration of recombinant adiponectin |
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suppresses hepatic glucose production,and reverses insulin resistance associated with |
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both lipoatrophy and obesity.The protective role of adiponectin is attributed to its anti- |
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inflammatory properties (e.g. ability to suppress expression of TNF-α and class A |
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scavenger receptor in macrophages) Recombinant adiponectin is a multimeric glycoprotein |
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containing amino acids Glu-19 to Asn- 244 of the adiponectin precursor protein fused to an |
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N- terminal histidine tag.Monomeric glycosylated adiponectin migrates at an apparent |
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molecular weight of approximately 35.0 kDa by SDS PAGE analysis under |
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reducing conditions. |
| Disease/ResearchGroup: Diabetes/WeightRegulation,Inflammation |
| Human Adiponectin: |
RGHHHHHHHH ETTTQGPGVL LPLPKGACTG WMAGIPGHPG |
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HNGAPGRDGR DGTPGEKGEK GDPGLIGPKG DIGETGVPGA |
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EGPRGFPGIQ GRKGEPGEGA YVYRSAFSVG LETYVTIPNM |
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PIRFTKIFYN QQNHYDGSTG KFHCNIPGLY YFAYHITVYM |
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KDVKVSLFKK DKAMLFTYDQ YQENNVDQAS GSVLLHLEVG |
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DQVWLQVYGE GERNGLYADN DNDSTFTGFL LYHDTN |
| Murine Adiponectin: |
RGHHHHHHHH VTTTEELAPA LVPPPKGTCA GWMAGIPGHP |
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GHNGTPGRDG RDGTPGEKGE KGDAGLLGPK GETGDVGMTG |
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AEGPRGFPGT PGRKGEPGEA AYVYRSAFSV GLETRVTVPN |
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VPIR FTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY |
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MKDVKVSLFK KDKAVLFTYD QYQEKNVDQA SGSVLLHLEV |
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GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF LLYHDTN |
| Estimated pI: |
Human Adiponectin: 6.20 |
Accession #: |
Human Adiponectin: Q15848 |
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Murine Adiponectin: 6.32 |
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Murine Adiponectin: Q60994 |
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| NCBI Gene ID: |
Human Adiponectin: 9370 |
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Murine Adiponectin: 11450 |
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