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857 次動脈粥樣硬化中血流紊亂會損害MerTK介導的主動脈內皮細胞的胞葬作用 2024-12-9
Disturbed flow impairs MerTK-mediated efferocytosis in aortic endothelial cells during atherosclerosisKeywords: Disturbed flow; MerTK; RNA-seq; atherosclerosis; efferocytosis; prot
811 次機械敏感的多囊蛋白1促進骨膜干/祖細胞在骨折愈合中的骨軟骨分化 2024-12-9
Mechanosensitive protein polycystin-1 promotes periosteal stem/progenitor cells osteochondral differentiation in fracture healingKeywords: Fracture healing; Mechanical stress; Peri
709 次 TNFSF12/TWEAK調節結腸炎性成纖維細胞并促其與單核細胞相互作用 2024-12-2
The TNFSF12/TWEAK Modulates Colonic Inflammatory Fibroblast Differentiation and Promotes Fibroblast-Monocyte InteractionsKWS：TNFSF12/TWEAK；Colonic Inflammatory Fibroblast；Differ
662 次 miR-342-5p通過抑制 MYC增強內皮細胞對剪切力的動脈化響應 2024-12-2
miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYCKeywords: MT: Non-coding RNAs; Notch; arterialization; end
901 次激活的SIRT1 通過增強 H 型血管生成和骨形成的耦聯來促進骨修復 2024-11-25
SIRT1 activation promotes bone repair by enhancing the coupling of type H vessel formation and osteogenesisKWS：SIRT1；bone repair；type H vessel formation；osteogenesis骨缺損可由感
1337 次血管內皮細胞機械敏感基因在動脈粥樣硬化形成和治療中的研究進展 2024-11-25
Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosisKeywords: Atherosclerosis; Blood flow; Endothelial cell; M
782 次 CD97 在壓縮下通過 Rap1a/ERK 通路抑制破骨細胞分化 2024-11-18
CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compressionSubject terms: Orthodontics, Cell signalling正畸治療是通過正畸牙齒移動（OTM）矯正咬合不正。OTM 是一種
1984 次 Piezo1 介導的機械轉導導致血流紊亂誘導的動脈粥樣硬化內皮炎癥 2024-11-18
Piezo1‐Mediated Mechanotransduction Contributes to Disturbed Flow‐Induced Atherosclerotic Endothelial InflammationKeywords: Piezo1; atherosclerosis; endothelial cells; inflammati
806 次綠茶化合物EGCG在子癇前期的體外靜態和剪切應力模型中的抗氧化作用 2024-11-16
EGCG, a Green Tea Compound, Increases NO Production and Has Antioxidant Action in a Static and Shear Stress In Vitro Model of PreeclampsiaKeywords: EGCG; NO; antioxidant; endotheli
798 次電壓門控性鈣通道α2δ亞基-1調控結腸癌進展并影響其微環境 2024-10-28
CACNA2D1 regulates the progression and influences the microenvironment of colon cancerKeywords: CACNA2D1; Colon cancer; Fibroblast; Voltage-gated calcium channel; p53.近年來，由于化
670 次人牙周膜間充質基質細胞通過旁分泌和細胞接觸介導對CD4+T的免疫調節 2024-10-28
Paracrine- and cell-contact-mediated immunomodulatory effects of human periodontal ligament-derived mesenchymal stromal cells on CD4+ T lymphocytesKeywords: CD4+ T lymphocytes; Co-
789 次衰老誘導內皮受損金屬蛋白酶17脫落連接粘附分子-A導致動脈重塑 2024-10-28
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17Keywords: Aging; Endothelium dysfunction; F11R; Junc
967 次 BACH1 基因的缺失通過減少內皮炎癥減輕動脈粥樣硬化 2024-10-28
Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial InflammationKeywords: BACH1; YAP; atherosclerosis; endothelial inflammation; hemodynamics.動脈粥樣硬化是冠狀動脈
1873 次 Cre-LoxP 系統助力條件性基因敲除動物模型研究 2024-10-25
在生物醫學研究和基因功能探索中，條件性基因敲除技術占據了舉足輕重的地位。其中，Cre-LoxP 系統以其獨特的工作原理和廣泛的應用場景，成為了研究基因功能不可或缺的利器。今天，我們就來深入了
721 次流體剪切應力通過NKG2D增強自然殺傷細胞對循環腫瘤細胞的細胞毒性 2024-10-25
Fluid shear stress enhances natural killer cell's cytotoxicity toward circulating tumor cells through NKG2D-mediated mechanosensingTopics：Mechanical stress, Cytotoxicity, Degr
888 次與體外循環相關剪切應力誘導單核細胞炎性細胞因子和壞死性凋亡的表達 2024-10-25
Shear stress associated with cardiopulmonary bypass induces expression of inflammatory cytokines and necroptosis in monocytesKeywords: Calcium signaling; Cardiology; Cytokines; Inf
850 次線粒體蛋白去琥珀�；ㄟ^調節線粒體穩態介導壓縮誘導的椎間盤退變 2024-10-25
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasisSubject terms: Dise
1019 次電壓門控性鈣通道α2/δ亞基-1調控結腸癌的進展并影響結腸癌的微環境 2024-10-21
近年來，由于化療的進步和分子靶向藥物的出現，結腸癌（CC）的治療結果有所改善。離子轉運體（Ion transporters）在細胞功能中起著至關重要的作用，近年來作為癌癥的潛在治療靶點而受到關注。闡
869 次衰老致內皮剪切應力感損去整合素金屬蛋白酶介導粘附分子脫落動脈重塑 2024-10-21
隨著年齡的增長，心血管系統發生了重要變化，包括血管硬度升高和異常重塑。研究表明，與衰老相關的小阻力動脈重塑可以獨立于全身血壓的變化而發生。研究已表明，小阻力動脈會因血流的持久變化或
837 次骨細胞通過激活整合素α5調節雄性小鼠對機械負荷的骨合成代謝反應 2024-10-14
機械敏感的骨組織根據機械負荷調整其結構。骨細胞（Osteocytes）是骨組織中主要的機械感覺細胞，可以檢測來自腔隙-小管網絡的機械信號，并將骨合成代謝分子釋放到骨基質中，以調節骨表面的骨重