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114 次 神經(jīng)系統(tǒng)中關(guān)鍵受體NK3R的功能作用及相關(guān)實驗的介紹 2025-7-10
NK3R（速激肽受體3）是由TACR3基因編碼的一種蛋白質(zhì)。它屬于速激肽受體家族，是一種典型的G蛋白偶聯(lián)受體。NK3R發(fā)揮功能的關(guān)鍵在于結(jié)合其高親和力配體——神經(jīng)激肽B(NKB)。NK3R不僅參與
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182 次 壓力響應型 miRNA - 5703 的過表達抑制壓力誘導的肝癌生長和轉(zhuǎn)移 2025-7-9
Overexpression of pressure-responsive miRNA-5703 inhibits pressure-induced growth and metastasis of liver cancerKeywords: liver cancer; metastasis; miRNA-5703; portal hypertension;
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196 次 成纖維細胞中張力敏感的 HOX 基因表達用于差異瘢痕形成 2025-7-8
Tension-sensitive HOX gene expression in fibroblasts for differential scar formationKeywords: Scar formation, Hypertrophic scar; Keloid; Wound healing; Tension; Tension change; Ten
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265 次 C/EBPβ 拮抗劑誘導巨噬細胞促炎極化增強抗腫瘤免疫 2025-7-3
The C/EBPβ antagonist peptide lucicebtide (ST101) induces macrophage polarization toward a pro-inflammatory phenotype and enhances anti-tumor immune responsesKeywords: C/EBP&b
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312 次 小鼠主動脈應力激活平滑肌細胞適應性程序維持強度防動脈瘤和夾層 2025-6-30
Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in MiceKeywords: aort
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374 次 成骨細胞線粒體氧化應激或自噬減少不足以模擬衰老對骨機械反應性損害 2025-6-24
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsivenessKeywords:
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223 次 苔蘚抑素-1（Bryostatin-1）通過抑制內(nèi)皮細胞自噬改善動脈功能 2025-6-24
Bryostatin-1 improves function in arteries with suppressed endothelial cell autophagyKeywords: Aging; Bryostatin-1; Endothelial cell; Nitric oxide.內(nèi)皮功能障礙是心血管衰老的標志，內(nèi)
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268 次 Piezo1 對抗與衰老相關(guān)的皮質(zhì)骨丟失 2025-6-24
Piezo1 opposes age-associated cortical bone lossKeywords: Piezo1; age-associated bone loss; endocortical bone resorption; mechanical stimulation.衰老會導致松質(zhì)骨和皮質(zhì)間隔的骨質(zhì)流失
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257 次 機械激活的間充質(zhì)衍生骨細胞通過細胞外囊泡介導的機制驅(qū)動血管生成 2025-6-23
Mechanically activated mesenchymal-derived bone cells drive vessel formation via an extracellular vesicle mediated mechanismKeywords: Osteoblast; VEGF; angiogenesis; mechanobiology
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189 次 血管炎性疾病和內(nèi)皮表型 2025-6-17
Vascular Inflammatory Diseases and Endothelial PhenotypesKeywords: EC phenotypes; endothelial cell; inflammation; vascular diseases.內(nèi)皮細胞排列在管腔表面，充當分隔血液和周圍組織的
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152 次 微管蛋白乙酰化增強機械應力下小梁網(wǎng)細胞的微管穩(wěn)定性 2025-6-16
Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical StressKeywords: trabecular meshwork, glaucoma, tubulin acetylation, mechanical stre
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336 次 拉伸誘導的內(nèi)皮細胞單層損傷的相關(guān)研究 2025-6-10
Stretch-induced damage in endothelial monolayersKeywords: Aging; Cell mechanics; Endothelium; Mechanobiology; Senescence; Stretch.由于血流的脈動性，包括流體剪切力、壓力和循環(huán)拉伸在
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373 次 視網(wǎng)膜神經(jīng)節(jié)細胞經(jīng)IL-12-SCGF-β串擾誘導干細胞衍生的神經(jīng)保護作用 2025-6-9
Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalkKWS：Retinal ganglion cells；stem cell；neuroprotection；IL-12；SCGF-β；cross
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437 次 血管內(nèi)皮-間充質(zhì)串擾通過 Notch 信號驅(qū)動人成骨細胞的成骨分化 2025-6-4
Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signalingKeywords: Co-culture; Endothelial cells; Notch signaling; Osteoblast
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359 次 TRPV4 抑制劑和機械負荷對減輕炎癥的協(xié)同作用 2025-6-3
Synergetic role of TRPV4 inhibitor and mechanical loading on reducing inflammationKeywords: anti-inflammatory phenotype; inhibition, mechanical loading; macrophage polarization; mi
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402 次 I 類 PI3Ks 激活小梁網(wǎng)細胞中拉伸誘導的自噬 2025-5-27
Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cellsKeywords: Autophagy; Glaucoma; Mechanical stress; PI3K; Primary cilia; Trabecular meshwork.眼壓升高（IO
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325 次 內(nèi)皮 IGFBP6 抑制血管炎癥和動脈粥樣硬化 2025-5-26
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosisKWS：IGFBP6；vascular inflammation；atherosclerosis動脈粥樣硬化通常發(fā)生在血流紊亂（DF）區(qū)域，例如動脈分支或彎
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391 次 c-REL串擾TXNIP-p38與非經(jīng)典NF-κB通路協(xié)調(diào)紊亂血流區(qū)動脈粥樣硬化 2025-5-20
Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathwaysKWS：c-REL, Shear stress, Endothe
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373 次 動脈粥樣硬化中血流誘導的內(nèi)皮細胞重編程 2025-5-19
Flow-induced reprogramming of endothelial cells in atherosclerosisSubject terms: Cell biology, Systems biology動脈粥樣硬化是一種主要影響動脈的多因素慢性炎癥性疾病。內(nèi)皮細胞功能障礙
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398 次 E2F1誘導IL-6炎癥循環(huán)介導癌癥免疫，預測T細胞表型轉(zhuǎn)換和治療反應 2025-5-13
E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsivenessKeywords: CD4 +/CD8 + T cells;
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